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Specialty Analytical Pioneers the Use of Thermo TSQ Quantum XLS Triple Quad GC/MS/MS
Developed for use in food, pharmaceutical and toxicology research labs Specialty Analytical is helping to pioneer the use of Thermo Instruments' TSQ Quantum XLS Triple Quad GC/MS/MS in environmental analysis.
TSQ Quantum XLS Triple Quad GC/MS/MS.
The system offers simultaneous quantification and structural confirmation through its innovative scan function, Quantitation-Enhanced Data-Dependent MS/MS (QED-MS/MS) along with industry leading levels of sensitivity and selectivity.
Contact the lab for more information or for a quote at 503-607-1331 or email us at info@specialtyanalytical.com.
Highly Selective Reaction Monitoring (HSRM) enables analysts to isolate and quantitate specific compounds even from the complex background of environmental matrices. Limiting the selected masses scanned in both the primary and tertiary Quadrupole MSs allows for incredibly low levels of sensitivity, parts per quadrillion (ppq) for most compounds.
Multiple Reaction Monitoring (MRM) allows for analysis of a large number of compounds in a single run. This can be applied to analysis of long analyte lists such as the 209 PCB Congeners list and long lists of pesticide residues, pharmaceuticals and other emerging compounds.
Sample extracts are introduced into a Trace Ultra gas chromatograph and compounds are separated on a capillary column before entering the triple quadrupole mass spectrometer. The triple quadrupole MS consists of two quadrupole MSs in series with a non mass resolving quadrupole MS in between that acts as a collision cell. The first or primary quadrupole MS (Q1) selects ions of know mass and accelerates them into the second MS where they collide with inert gas molecules (Argon) at higher pressure inducing fragmentation of the molecular ions into smaller fragment ions that can be further separated and detected by the third or tertiary quadrupole MS (Q3). Collision-induced dissociation (CID) and the fragment ions produced can be used for partial or complete structural determination and identification and to increase sensitivity. By looking at a unique ion fragment you can detect a given molecule in the presence of other molecules of the same nominal molecular mass reducing the background and, thereby, the limit of detection.